Chunshan gui and oatp1b1

WebIdentification, Kidetermination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17β-glucuronide transport Chunshan Guia, Brett Wahlgrena, Gerald H. Lushingtonb, and Bruno Hagenbucha,c,* WebThis type of analysis has been previously successfully used to determine the type of interaction of OATP1B1 with a wide range of physiological substrates and fibrates (Gui et al., 2009; Yamazaki ...

Cloning/Characterization of the Canine Organic Anion …

WebChunshan Gui a and Bruno Hagenbuch a, b Author ... nothing is known about their OATP1B1/1B3 ortholog. Therefore, we cloned and characterized the first canine organic … WebMar 1, 2024 · OATP1B1 has broad substrate specificity and the structures of its substrates/inhibitors are quite diverse (Hagenbuch and Gui, 2008). With the increasing number of structurally diverse substrates/inhibitors for OATP1B1, it’s almost impossible to reliably superimpose hundreds of these molecules to carry out 3D-QSAR analysis. grass valley ca housing https://grupo-vg.com

Identification, Ki determination and CoMFA analysis of nuclear …

WebAug 6, 2024 · A number of drug-drug and drug-food interactions have been associated with OATP1B1 and 1B3, affecting the pharmacokinetics and pharmacodynamics of their substrate drugs. 8–16 It has also been reported that many natural substances present in food or dietary supplements such as flavonoids could intact with OATP1B1 and 1B3 and … WebFeb 8, 2008 · Chunshan Gui, a Yi Miao, a Lucas Thompson, a Bret Wahlgren, a Melissa Mock, b Bruno Stieger, b and Bruno Hagenbuch a, c ... transport, we developed Chinese Hamster Ovary (CHO) cell lines stably expressing OATP1B1 or 1B3 at high levels. OATP1B1- and 1B3-mediated estradiol-17β-glucuronide uptake was inhibited by several … WebChunshan Gui1, Amanda Obaidat1, Rathnam Chaguturu2,3 and Bruno Hagenbuch*,1,2 ... hibitors for OATP1B1 and OATP1B3. We have used OATP1B1- or OATP1B3-expressing Chinese Hamster Ovary cells ... 2010, Volume 4 Gui et al. used this assay to screen the Prestwick library for modulators (inhibitors or stimulators) and confirmed several hits by chloe mawass

Development of a cell-based high-throughput assay to screen for ...

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Chunshan gui and oatp1b1

Effect of pregnane X receptor ligands on transport mediated by …

WebNov 1, 2009 · Search worldwide, life-sciences literature Search. Advanced Search WebWe have used OATP1B1- or OATP1B3-expressing Chinese Hamster Ovary cells on 96-well plates and determined uptake of fluorescein-methotrexate (FMTX). We validated the assay with known inhibitors and screened the well characterized Prestwick library of 1120 drugs.

Chunshan gui and oatp1b1

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WebAug 9, 2008 · Human organic anion transporting polypeptides (OATP) 1B1 and 1B3 are multispecific transporters that mediate uptake of amphipathic organic compounds into hepatocytes. The two OATPs contain 12 transmembrane domains (TMs) and share 80% amino acid sequence identity. WebDec 16, 2024 · OATP1B1, OATP1B3, and OATP2B1, with OATP1B3 showing the highest transport efficiency. The Kmvalues for OATP1B1-, OATP1B3-, and OATP2B1-mediated PSP uptake were 11.3 ± 1.5, 7.0 ±1.5, and 5.1 ±1.0...

WebChunshan Gui Brett Wahlgren Gerald Lushington Bruno Hagenbuch Evidence shows that drug-drug interactions can occur at the level of drug transporters such as the organic anion transporting... WebAug 6, 2024 · A number of drug-drug and drug-food interactions have been associated with OATP1B1 and 1B3, affecting the pharmacokinetics and pharmacodynamics of their …

WebChunshan Gui Organic anion transporting polypeptide 1B1 (OATP1B1) is a key hepatic uptake transporter whose inhibition could lead to adverse drug-drug and drug-food interactions. WebChunshan Gui, a Brett Wahlgren, a Gerald H. Lushington, b and Bruno Hagenbuch a, c, * ... Inhibition of OATP1B1-mediated estradiol-17β-glucuronide uptake by 37 nuclear …

WebAbstract: The two organic anion transporting polypeptides (OATPs) 1B1 and 1B3 are expressed at the sinusoidal membrane of hepatocytes. They have a broad and overlapping substrate specificity and transport many endobiotics and drugs.

WebAug 9, 2008 · Europe PMC is an archive of life sciences journal literature. Search life-sciences literature (Over 39 million articles, preprints and more) grass valley california fires todayWebFeb 8, 2008 · OATP1B1- and 1B3-mediated estradiol-17beta-glucuronide uptake was inhibited by several pregnane X receptor ligands in a concentration dependent way. … grass valley california firesWebChunshan Gui - College of Pharmaceutical Sciences, Soochow University, 199 Renai Road, Suzhou Industrial Park, ... polypeptides OATP1B1 and OATP1B3 are highly … grass valley california campgroundsWebIn this study, we investigated the molecular mechanism for this substrate selectivity of OATP1B1 by constructing OATP1B1/1B3 chimeric transporters and by site-directed … grass valley california fairgroundsWebJun 30, 2011 · Chunshan Gui et al. have confirmed that ursolic acid is a selective OATP1B3 and OATP1B1 inhibitor (Chunshan et al. 2010 ). Therefore, there may be an interaction between ursolic acid and rosuvastatin. A reasonable combination use of rosuvastatin and herbal medicines containing ursolic acid has important clinical value. grass valley california fire updateWebJun 30, 2011 · At present, Chunshan Gui et al. have confirmed that ursolic acid was the selective OATP1B3 and OATP1B1 inhibitor (Chunshan et al. 2010). Therefore, the drug … grass valley california grocery storesWebDec 24, 2024 · Taken together with our previous results 7 that the mutations of OATP1B1*5, *15 and CYP2C9*2, *3 significantly affect the transport and metabolism of glimepiride … grass valley california gold mine reopening