WebHuman ELF3 is 371 amino acids (aa) in length. It contains one PNT/pointed dimerization domain (aa 46-132), a protein stabilizing PEST sequence (aa 210-225), an A/T Hook region that binds to AT-rich DNA sequences (aa 236-252), and an ETS DNA binding domain (aa 273-355). ELF3 interacts with CREBBP, EP300, KU70 and KU86. WebELF3 and MYBL2 involved in cell cycle and DNA replication were tumor suppressors. MEG3, APEX1, and EZH2 were related with the cell epigenetic regulation in bladder cancer. Moreover, HOXB9 and EN1 that have their own motif were the transcription factors. ... vascular endothelial growth factor, and ErbB to activate their respective pathways, ...
临床医学(麻醉学)导师风采——孟志鹏
WebNov 28, 2024 · ELF3 is located within a region of focal amplification in lung adenocarcinoma. a Comparison of significantly focally amplified regions … WebAlthough this situation was much exaggerated under hypoxia, ELF3 silencing under hypoxia significantly attenuated angiogenic activity in endothelial cells by reducing the expression and secretion ... imax theater at the rim
Identification of β-catenin as regulatory target of Elf3. (a) GSEA ...
WebApr 8, 2024 · Importantly, ELF3 was in the top 97th percentile of hits (#22 of 752, ... T-cells, endothelial, stromal, macrophage, and B-cells. Reclustering was performed as above. ... WebFurther, continued NF-κB activation results in the overexpression and activation of other regulatory transcription factors, including E74-like factor 3 (ELF3) and endothelial PAS domain protein 1 (hypoxia inducible factor 2 alpha) (HIF-2α), which, in turn, further perpetuate OA disease via modulation of inflammatory and catabolic mediators,15 ... Weband endothelial cells, Elf3 belongs to the epithelium-specific ETS (ESE) subfamily of ETS transcription factors, which are expressed only in epithelial-rich tissues, such as stomach, imax theater birmingham