Webb1 jan. 1989 · In conclusion, Wy 27587 is a potent and selective inhibitor of the uptake of 5-HT in nerve terminals, relative to that of noradrenaline. It is also a potent inhibitor of the uptake of 5-HT into platelets, both in vitro and ex viva, with competitive kinetics and a prolonged duration of action. WebbThe intestinal ulcerogenic activity of the weak prostaglandin synthesis inhibitor drug Wy-4 1,770 [5H- dibenzo(a,d)-cyclohepten-5-ylidine] was contrasted with the potent synthesis …
Effect of the PKC inhibitor staurosporine on Wy-14,643-induced ...
Webb14 apr. 2024 · Small-molecule inhibition of FLT3 represents an attractive therapeutic strategy for this subtype of AML, although resistance from secondary FLT3 tyrosine kinase domain (FLT3-TKD) mutations is an emerging clinical problem. CCT241736 is an orally bioavailable, selective, and potent dual inhibitor of FLT3 and Aurora kinases. Webb1 okt. 2009 · The inhibitory effects of oxymatrine gradually increased as the concentration increased from 200 to 1000 mg/l for HBsAg and HBeAg, and from 200 to 400 mg/l for HBV-DNA. There was no inhibitory effect of oxymatrine at concentrations < 200 mg/l. No significant difference was seen between human IFN-α2b (positive control) and … how to get v pose for free
PubMed Central (PMC)
Webb1 aug. 1997 · Co-treatment of rotenone and WY-14,643 decreased focal DNA synthesis and mitosis and increased the incidence of apoptotic hepatocytes and alterations in the growth of hepatic focal lesions were investigated. The effect of rotenone treatment on [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid (WY-14,643) hepatic lesion growth … WebbWy 25093 is an inhibitor of the neuronal 5-hydroxytryptamine (5-HT) uptake process in vitro and in vivo, and may possess potential antidepressant activity. MedKoo … Webb1 aug. 2000 · Electromyographic activity was recorded in the masseter muscle to investigate whether the firing characteristics of single motor units (SMUs) were affected by muscle pain. Capsaicin was injected into the masseter to induce pain. The interspike interval (ISI) and recruitment threshold of SMUs were measured while subjects … how to get vpn on windows 11