Irf4 pathway
WebApr 19, 2024 · We have previously demonstrated that this model is dependent on the JMJD3-IRF4 pathway, with GSK-J4 treatment and Irf4 −/− mice being resistant to inflammatory pain (Achuthan et al., 2016). Mice were injected intraplantarly with saline, or combinations of GM-CSF, IFNβ, or DM-αKG, and pain monitored by a change in weight … WebApr 30, 2009 · IRF4 (also known as pip, MUM1, LSIRF, NFEM5, and ICSAT) is an IRF-family member that is restricted in expression to the immune system, a property it shares with its closely related family member IRF8. IRF4 and IRF8 have evolved as critical mediators of lymphoid-, myeloid-, and dendritic-cell development ( 1 – 5 ).
Irf4 pathway
Did you know?
WebInterferon regulatory factor 4 (IRF4) has critical roles in immune cell differentiation and function and is indispensable for clonal expansion and effector function in T cells. Here, we demonstrate that the AKT pathway is impaired in murine CD8 + T cells lacking IRF4. WebExpression of IRF4 and IRF8 is restricted to the lymphoid and myeloid lineages of the immune system ( 4 ), whereas they are crucial for B lymphocyte development and Th cell differentiation. In addition to a pro-inflammatory role, IRF5 is …
WebAug 1, 2024 · We demonstrated an IRF4‐mediated feedback signaling pathway between exercise and exercise‐induced exhaustion. When running, IRF4 was induced and then inhibited PTG‐associated glycogen synthesis, which eventually led to glycogen depletion and causing exhaustion. The glycogen contents in skeletal muscle was higher in MI4KO mice … WebIRF4 control IFN ␥ by an independent pathway through IRF1. A , HuT-102 cells were transfected with IRF4 siRNA. The up-regulation of Th1-related proteins was confirmed by Western blot.
WebThe significant enrichment of Th17 cell differentiation found in pathway analyses highlight the potential importance of this pathway in JIA etiology. Four candidate genes at genome‐wide significant loci ( SMAD2 , IL1RAP , IL6ST , and … WebJan 1, 2015 · IRF4 regulates MYC expression in ALCL. ALCL survival depends on IRF4/MYC signaling. Abstract Anaplastic large cell lymphoma (ALCL) is a distinct entity of T-cell lymphoma that can be divided into 2 subtypes based on the presence of translocations involving the ALK gene (ALK + and ALK − ALCL).
WebNov 7, 2024 · Protein kinase B (Akt)/STAT6-JMJD3/IRF4 pathway was found crucial for M2 differentiation of dMϕ induced by receptor activator of nuclear factor-κB ligand (RANKL) at the maternal-fetal interface in vitro and in vivo, and the activation of Akt/STAT6-JMJD3/signaling induced decidual M2 macrophage polarization to promote smooth …
WebOverview. Interferon regulatory factor 4 (IRF4) is a gene that encodes a transcription factor protein that functions as a regulator of interferons and interferon-inducible genes. The … desin pe chordsWebIrf4 is a critical regulator of many aspects of B- and T-cell differentiation and cell metabolism (Biswas et al., 2012; De Silva, Simonetti, Heise, & Klein, 2012; Eguchi et al., … desing thinkinWebJun 21, 2024 · The TCR pathways leading to IRF4 are unclear, and our data shows for the first time that downstream of the TCR and ITK, the Ras/MAPK pathways leads to IRF4 … desin marine \\u0026 industry svc. ltdWebMar 21, 2024 · IRF4 (Interferon Regulatory Factor 4) is a Protein Coding gene. Diseases associated with IRF4 include Skin/Hair/Eye Pigmentation, Variation In, 8 and Whipple … des in kerberos authenticationWebApr 11, 2024 · 多人被撤销基金项目!. 国家基金委公布一批科研不端案件处理结果. 2024-04-11 21:49:00 来源: 材料科学与工程 北京 举报. 371. 分享至. 2024年查处的不端行为案件处理结果通报(第一批次). 近期,经国家自然科学基金委员会监督委员会调查审议、国家自然科学 … des in heartdesin marine \u0026 industry svc. ltdWebThe 27.5 mile Joe Louis Greenway is a planned biking and walking trail that extends from the Detroit Riverfront to Highland Park, Dearborn, and Hamtramck. It also includes connectors … des injury lawyer california