Phospho smad3
WebSMAD3 belongs to the SMAD family of proteins. They are similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. WebSmad3 Protein / metabolism* Transforming Growth Factor beta / metabolism* Substances Collagen Type X Core Binding Factor Alpha 1 Subunit Proto-Oncogene Proteins RNA, Small Interfering Smad2 Protein Smad3 Protein Transforming Growth Factor beta Osteocalcin Cyclin D1 Histone Deacetylases Grant support
Phospho smad3
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WebPhospho-Smad3 (Ser423/425) (D12E11) Rabbit mAb recognizes endogenous levels of Smad3 protein when phosphorylated at Ser422 only, at both Ser423 and Ser425, or at Ser422, Ser423, and Ser425. This antibody also weakly recognizes the equivalent phospho-residues of Smad2 protein (Ser464, Ser465, and Ser467). Species Reactivity: WebBoster Bio Anti-Phospho-SMAD3 S423/S425 Antibody catalog # P00059. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. Supplied as 100μL in Liquid …
WebMar 21, 2024 · SMAD3 (SMAD Family Member 3) is a Protein Coding gene. Diseases associated with SMAD3 include Loeys-Dietz Syndrome 3 and Aortic Aneurysm, Familial Thoracic 1 . Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and TGF-beta receptor signaling activates SMADs .
WebSep 30, 1997 · A Smad3 protein in which the three C-terminal serines have been replaced by aspartic acids is also a dominant inhibitor of TGF-β signaling, but can activate plasminogen activator inhibitor 1 (PAI-1) transcription in a ligand-independent fashion when its nuclear localization is forced by transient overexpression. WebPurity/Specificity. Anti-SMAD3 pT179 affinity-purified antibody is directed against the phosphorylated form of human Smad3 protein at the pT179 residue. The product was affinity purified from monospecific antiserum by immunoaffinity purification. Antiserum was first purified against the phosphorylated form of the immunizing peptide.
WebJul 1, 2012 · This discovery has expanded the understanding of the significance and complexity of TGFβ signaling through Smads. This review highlights recent advances …
WebThis antibody is phospho specific for dual phosphorylated pS423 and pS425 of Smad3. Stimulation with 2 ng/ml TGF-beta for 1 hour is suggested. Purity/Specificity. This affinity … how did web dubois challenge stereotypesWebThis antibody is phospho specific for dual phosphorylated pS423 and pS425 of Smad3. Stimulation with 2 ng/ml TGF-beta for 1 hour is suggested. Purity/Specificity This affinity-purified antibody is directed against the phosphorylated form of human Smad3 protein at the pS423 and pS425 residues. how many sweetarts in a bagWebab52903 detects Smad3 phosphorylated on Serine 423 and Serine 425. This Smad3 antibody may also detect Smad1, Smad2 and Smad5 phosphorylated at the equivalent sites. Tested applications Suitable for: … how many sweethearts in a bagWebAlthough the upregulation of Smad3 in VSMCs had no significant effect on total p27 levels, Smad3 did stimulate the phosphorylation of p27 at serine-10 as well as the nuclear export of p27, events associated with cell proliferation. how did weather report get his standWebSmad3 and phospho-Smad3 are potential markers of invasive nonfunctioning pituitary adenomas Chunhui Liu,1,2 Zhenye Li,1–3 Dan Wu,4 Chuzhong Li,1–3 Yazhuo Zhang1–3 … how many sweetie pie restaurants are openWebApr 7, 2024 · Moreover, deletion of Smad3 from db/m or db/db mice almost competitively blocked SARS-CoV-2 N-induced Ripk3/MLKL expression and phospho-MLKL level (Fig. 1v, … how many sweetheart movies are thereWebThe SMAD3 gene provides instructions for making a protein involved in transmitting chemical signals from the cell surface to the nucleus. This signaling pathway, called the transforming growth factor-beta (TGF-β) pathway, allows the environment outside the cell to affect cell function, including how the cell produces other proteins. how many sweet green stores are there