Sclc and hyponatremia

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August undefined, 2024

WebHypovolemic (volume depletion) hyponatraemia occurs when the total body water and sodium content are both decreased but the relative decrease in total body sodium is greater than the decrease in total body water. Causes include: Medications, especially thiazide diuretics. Endocrine disorders (primary adrenal insufficiency). Webwith hyponatremia; retrospective studies showed an incidence of about 20–44% in this setting.2,5–7 According to Hermes and colleagues the incidence of hyponatremia in small-cell lung cancer (SCLC) is 18.9% and correlates with disease stage at diag-nosis; 24% in patients with extensive disease com-pared with 11% in those with limited disease ...

Hyponatremia Improvement Is Associated with a Reduced Risk of …

Web7 May 2024 · For the approximately 30% of patients with SCLC who have limited-stage disease at the time of diagnosis (ie, tumors confined to the hemithorax of origin, the mediastinum, or the supraclavicular... Web22 May 2012 · Hyponatremia is an electrolyte abnormality commonly encountered in oncology practice and is usually defined by a serum sodium level <135 mEq/L [1, 2]. Although many cases are asymptomatic, … roche hemolysis index

Small Cell Lung Cancer Patient with Profound Hyponatremia and A…

WebHyponatremia is decrease in serum sodium concentration < 136 mEq/L ( < 136 mmol/L) caused by an excess of water relative to solute. Common causes include diuretic use, diarrhea, heart failure, liver disease, renal disease, and the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Web1 Nov 2013 · Hyponatremia is a common feature in oncology practice , occurring most frequently in patients with SCLC . A quarter of all patients with SCLC were identified as having sodium [Na +] of <136 mmol/L in a large analysis of nine consecutive clinical trials in Denmark and Sweden (n = 1684) . Web1 Aug 2024 · Small-cell lung cancer (SCLC) is an aggressive disease with distinct pathological, clinical, and molecular characteristics from non–small-cell lung cancer. SCLC has high metastatic potential, resulting in a clinically poor prognosis. Early concurrent chemo-radiation is the standard of care for limited-stage SCLC (LS-SCLC). Prophylactic … roche hemlibra

Differential diagnosis of symptoms - BMJ Best Practice

Hyponatremia - Symptoms and causes - Mayo Clinic

WebBetween 10% to 15% of people with SCLC develop SIADH. Nearly 50% may have a milder form of the condition. You're more likely to have this complication if your cancer has spread outside of your lungs. Web17 May 2024 · Hyponatremia occurs when the concentration of sodium in your blood is abnormally low. Sodium is an electrolyte, and it helps regulate the amount of water that's in and around your cells. In hyponatremia, one or more factors — ranging from an underlying … roche hemofiliaWebHyponatremia is a condition where sodium levels in your blood are lower than normal. In many cases, too much water in your body dilutes sodium levels. It’s also possible to lose too much sodium. You may have a short-term treatment plan or a long-term plan. Urology … roche her2

"WebP < 0.001). Lastly, the correction of hyponatremia in certain cancers (e.g., SCLC) has been shown to improve survival likelihood, providing nascent evidence that correction of hyponatremia may be critical to address.16 Hyponatremia may also impact response to cancer therapy. In a study of non–small cell lung cancer patients treated with " - Sclc and hyponatremia

Sclc and hyponatremia

Association of ANP and AVP with hyponatremia in SCLC

WebIt was approved by China Food and Drug Administration (CFDA) for the treatment of patients with both non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) and progression after ＞2 lines of chemotherapy. Web8 Jul 2015 · Since SCLC also causes SIADH and the laboratory tests revealed the presence of hyponatremia and hypochloremia, the muscle weakness may have also been associated with SIADH, as well as LEMS. However, laboratory evidence is required to determine whether the symptoms should be attributed to SIADH rather than LEMS.

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Web10 Apr 2024 · We added postoperative hyponatremia as a risk factor, along with previously reported known risk factors. 4, 5 Male sex, age (85 years or older), ... The occurrence of hyponatremia in SCLC and the influence on prognosis: a retrospective study of 453 patients treated in a single institution in a 10-year period. Lung Cancer, 68 ... Web24 Oct 2024 · Hyponatremia was defined as a serum sodium concentration below 135 mmol/L and then assigned into two groups: mild (130 to 134 mmol/L) and severe (below ≤ 129 mmol/L) hyponatremia. Hyponatremia was detected in 85 (22.8%) patients (mild …

Web28 Mar 2008 · My dad had sclc and a wicked bout with low sodium (hyponatremia). This is VERY common with SCLC, especially if the adrenal glands have been visited with mets. You need to be very cautious with low sodium, as it can lead to other problems, including convulsions. The treatment the oncologist put daddy on was declomycin. Web1 Jun 2024 · SCLC is the most common malignancy associated with hyponatremia, typically due to SIAD and affecting nearly one-quarter of patients with this diagnosis., SCLC is followed in frequency of occurrence by head and neck …

Web20 Jul 2024 · Hyponatremia can be classified into 5 main types. Hypovolemic hyponatremia: total body water decreases, but total body sodium decreases to a greater extent. The extracellular fluid volume is also decreased. Euvolemic hyponatremia: total body water … Web14 Apr 2024 · Abstract. Purpose: Immune checkpoint inhibitor (ICI) maintenance therapy is standard of care for frontline management of extensive stage small cell lung cancer (ES SCLC). However, overall survival benefit of addition of ICI maintenance to frontline ES SCLC treatment is modest and further improvement is needed. We hypothesized that addition of …

WebOne-third of patients with SCLC and hyponatremia have no evidence of ectopic AVP production. Studies, therefore, have sought to distinguish patients with hyponatremia caused by elevated AVP versus those with ectopic atrial natriuretic peptide. Gross et al 48 found that 17 of 21 SCLC cell lines expressed atrial natriuretic peptide. Eleven of ...

Web28 Oct 2024 · Most of the available data focus on thoracic tumors, especially small-cell lung cancer (SCLC), where hyponatremia is frequently related to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Few studies specifically focus on non-small … roche hiresWeb7 Feb 2006 · Hyponatremia occurs at presentation in ∼15% of patients with small cell lung cancer (SCLC) in retrospective studies ( 3 ), 30% in our previous prospective study of patients with SCLC ( 4 ), and 1% of patients with non–small cell lung cancer (NSCLC; ref. 3 ). roche herceptinWebHyponatremia was also frequently observed in cancer patients. Previous studies reported that hyponatremia (<135 mEq/L) was present in 47% of newly admitted cancer patients,2) and ... (SCLC) (27.3%) and esophageal cancer (18.1%) were signiﬁcantly higher than those of patients with other types of cancer (p = 0.021 and 0.043, respectively; Table roche her2 lowWeb23 Sep 2024 · Symptoms include: Mild hyponatraemia - lack or loss of appetite (anorexia), headache, feeling sick (nausea), being sick (vomiting), and lack of energy and enthusiasm (lethargy). Moderate hyponatraemia - personality change, muscle cramps and weakness, confusion, and lack of muscle co-ordination (ataxia). Severe - drowsiness and fits … roche herediaWeb10 Sep 2024 · Albeit underdiagnosed, SIADH is one of the most common causes of euvolemic hyponatremia, especially in patients with small cell lung cancer (SCLC) 8. Non-small cell lung cancer (NSCLC), breast... roche hemophiliaWeb22 May 2012 · Among cancer patients, hyponatremia occurs most frequently with small cell lung cancer (SCLC). In an analysis of nine consecutive clinical trials conducted jointly at four hospitals in Denmark and Sweden, a serum sodium level <136 mEq/L was identified in 415 of 1,684 SCLC patients (24.6%) [ 4 ]. roche hertfordshireWebHyponatremia, could cause a series of clinical symptoms, reduce the response to the treatment of tumor chemotherapy or ra-diotherapy in SCLC patients, and increase their Abstract. – OBJECTIVE: Hyponatremia is one of the most frequently encountered electrolyte disorder in small cell lung cancer (SCLC) pa-tients. roche hillsboro