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Targeted cisplatin

WebApr 13, 2024 · Gene scissors find target for testicular cancer therapy Bonn researchers uncover contribution of protein degradation processes to cisplatin resistance in germ cell tumors: Cisplatin is used successfully in the chemotherapy of testicular cancer. WebDec 9, 2024 · Ovarian cancer (OC) is the 11th most common cancer in women and the fifth leading cause of cancer-related death in the world, 1 with an estimation of 314,000 newly diagnosed cases and ...

Concomitant radiation therapy and targeted cisplatin …

WebApr 13, 2024 · Researchers at the University Hospital Bonn (UKB) have now been able to elucidate a mechanism underlying cisplatin resistance in testicular cancer. Using CRISPR … WebJan 27, 2024 · Patients with locally advanced disease also elicited a better median OS with the triplet (n = 77) at 19.2 months compared with 13.7 months with the doublet (n = 41). Further, the median PFS was 9.3 months with the addition of nab-paclitaxel vs 7.6 months with gemcitabine and cisplatin alone. “At the end of the day, this study did not meet its ... psychotherapie apeldoorn https://grupo-vg.com

Advanced cisplatin nanoformulations as targeted drug

WebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, generating genetic and epigenetic changes that lead to the generation of resistance and the activation of intrinsic resistance mechanisms in cancer cells. Among them, we can find mutations, … WebTargeted nanomedicine shows great promise in delivering cisplatin for maximizing efficacy while minimizing off-target toxicity. This article surveyed the recent progress and challenges of targeted nanomedicine in managing resistance and toxicity of cisplatin in both fundamental and clinical aspects. Particularly, we focused on three major ... WebThe structure of the [Pd 2 L 4 ⊃(cisplatin) 2](BF 4) 4 host–guest adduct has been confirmed by 1 H NMR spectroscopy, HR-ESMS and X-ray crystallography. Additionally we have demonstrated that the cage–cisplatin host–guest adduct can be quantatively disassembled upon the addition of a competing ligand , releasing the cisplatin guest. hot air up or down

Traditional chemotherapy superior to new alternative for …

Category:Pembrolizumab Added to Gemcitabine/Cisplatin Improves OS in …

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Targeted cisplatin

Nab-Paclitaxel Plus Gemcitabine and Cisplatin Fails to Meet OS …

WebMay 1, 2024 · Targeted nanomedicine shows great promise in delivering cisplatin for maximizing efficacy while minimizing off-target toxicity. This article surveyed the recent progress and challenges of targeted nanomedicine in managing resistance and toxicity of cisplatin in both fundamental and clinical aspects. WebApr 6, 2024 · Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. …

Targeted cisplatin

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WebKeywords: cisplatin‐resistance, nano‐zinc carriers, non‐small cell lung cancer, small interfering RNA, targeted therapy Abstract The ligands are combined with nano‐zinc hydroxide carriers to guide aptamer and siUSP14 to specifically bind to the surface of DDP‐resistant A549/DDP cells. WebApr 15, 2024 · Cell Death & Disease - Targeted CUL4A inhibition synergizes with cisplatin to yield long-term survival in models of head and neck squamous cell carcinoma through a DDB2-mediated mechanism Skip to ...

WebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, … WebNiraparib (Zejula) may be used in some situations to treat ovarian cancer. In women with or without a BRCA gene mutation: Niraparib might be used as maintenance treatment for …

WebSep 2, 2024 · As we know that cisplatin is a first-line therapeutic drug for lung cancer, the applicability of cisplatin to the targeted site needs therapeutic efficiency with nil side effects along with increased solubility of the drug. Currently, nanotechnology-based targeted therapy looks as an outstanding efficient therapeutic among the oncotherapeutics. WebMechanically, we found that miR-34c targeted the MET gene, thereby inhibiting the phosphorylation of PI3K and AKT to activate Bad. As a result, miR-34c reduced resistance of ovarian cancer cells to cisplatin-induced apoptosis. ... Cisplatin is a platinum-based cytotoxic agent that is commonly used for the treatment of various types of malignant ...

WebMethods. Twenty-five patients diagnosed with stage III/IV pyriform sinus squamous cell carcinoma treated with supradose, intra-arterial targeted cisplatin, and concomitant radiotherapy were analyzed for response rates, survival, pattern of failure, and function of the preserved organs.

WebJan 26, 2024 · The addition of pembrolizumab (Keytruda) to gemcitabine and cisplatin elicited a significant improvement in overall survival (OS) vs gemcitabine and cisplatin … psychotherapie aok bayernhot air vulcanizationWebJun 10, 2024 · NUS chemists have developed a mitochondria-targeted fluorescent probe for real-time imaging of clinically important anticancer drug cisplatin in live cancer cell … psychotherapie approbationsordnungWebSep 18, 2024 · National Center for Biotechnology Information hot air websiteWebAug 28, 2024 · Targeting androgen-receptor (AR) signaling in metastatic bladder cancer with enzalutamide (Xtandi) in combination with gemcitabine and cisplatin is considered a safe and tolerable regimen, based on the results of a phase I/Ib trial. 1. The dose-escalation phase included patients with AR-positive and AR-negative disease and followed the 3+3 … psychotherapie approbation arztWebKeywords: cisplatin‐resistance, nano‐zinc carriers, non‐small cell lung cancer, small interfering RNA, targeted therapy Abstract The ligands are combined with nano‐zinc … psychotherapie approbation prüfungWebMay 1, 2024 · Abstract. Since its license in 1978, cisplatin has proved to be one of the most successful chemotherapeutic agents in the world. However, two acute challenges facing … psychotherapie approbation beantragen