WebApr 13, 2024 · Abstract Oocyte maturation arrest is one of the important causes of female infertility, but the genetic factors remain largely unknown. PABPC1L, a predominant poly(A)-binding protein in Xenopus, mo... Bi‐allelic pathogenic variants in PABPC1L cause oocyte maturation arrest and female infertility EMBO Molecular Medicine WebTRIP13 is a member of the AAA+ ATPase family, a family known for mechanical forces derived from ATP hydrolase reactions. The TRIP13 gene has been shown to interact with …
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WebJul 31, 2014 · TRIP13 is the mouse orthologue of pachytene checkpoint 2 (Pch2), a checkpoint for synapsis before DSB repair and recombination in yeast and Caenorhabditis elegans 7, 8. In mice, TRIP13 mediates... WebMar 14, 2024 · Studies have shown that TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint because TRIP13 catalyzes the conversion of C … business center microsoft dynamics
TRIP13 promotes tumor growth and is associated with poor
WebTRIP13 is correlated with poor prognosis of bladder cancer by promoting proliferation, invasion, and epithelial-mesenchymal transition. Our study demonstrated that TRIP13 … WebMay 1, 2024 · In 2024, TRIP13 was also found to be responsible for oocyte MI arrest (11), and TBPL2 mutations were found to be associated with OMA and fertilization disorders in … WebSep 21, 2024 · HORMAD2 Deficiency Prevents Elimination of Trip13 Mutant Oocytes that Have Complete Synapsis but Unrepaired Meiotic DSBs, Restoring Female Fertility. Taken alone, the rescue of Spo11 −/− oocytes by Chk2 deletion suggests that severe asynapsis leads to CHK2 activation and signaling to mediate oocyte elimination. This led us to … h and r block evans colorado